Susac Syndrome: an uncommon cause of impaired vision

Neurol Sci. 2022 Jan 10. doi: 10.1007/s10072-022-05865-8. Online ahead of print.ABSTRACTA 35-year-old Caucasian woman presented an abrupt onset of bilateral impaired vision, and arrived to our attention two weeks later. She had a previous episode of mild dizziness. She underwent a fluorescein angiography showing branch retinal artery occlusions and a brain magnetic resonance imaging (MRI) revealing several supraand infratentorial FLAIR-hyperintense white matter lesions, two with contrast enhancement. Thrombophilic, autoimmune and infective (including Human Immunodeficiency Virus, Borrelia burgdorferi, Hepatitis B Virus, Hepatitis C Virus, Herpes Simplex Virus 1-2, Varicella Zoster Virus) screening was negative. Cerebrospinal fluid analysis showed intrathecal IgG synthesis. We suspected a Primary Central Nervous System Vasculitis, and intravenous steroids were started. Three months later a second brain MRI showed seven new lesions without contrast enhancement, and she revealed a cognitive impairment and bilateral hearing loss. Reviewing the clinical history and MRI, she fulfilled diagnostic criteria for Susac syndrome. She had two cycles of cyclophosphamide, and recovered in 6 months and then remained stable with metotrexate.PMID:35006444 | DOI:10.1007/s10072-022-05865-8
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research

Related Links:

Conclusion Our work establishes a TPE instrument and measurement method for noninvasive metabolic assessment of the human retina. This approach opens the possibility for monitoring eye diseases in the earliest stages before structural damage to the retina occurs.Funding NIH, Research to Prevent Blindness, Foundation for Polish Science, European Regional Development Fund, Polish National Agency for Academic Exchange, and Polish Ministry of Science and Higher Education.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Thread Starter Can you get a job whilst studying medicine? Follow 1 hour ago 1 hour ago Quote: Originally Posted by jessicanaude Okay, thank you! Lectures etc are timetabled pretty much 9-5 every day. Some work at weekend but it’s hard to juggle your workload
Source: The Student Room - Category: Universities & Medical Training Authors: Tags: Medicine Source Type: forums
AbstractMoyamoya disease (MMD) is a rare cerebrovascular disease characterized by progressive spontaneous bilateral occlusion of the intracranial internal cerebral arteries (ICA) and their major branches with compensatory capillary collaterals resembling a “puff of smoke” (Japanese: Moyamoya) on cerebral angiography. These pathological alterations of the vessels are called Moyamoya arteriopathy or vasculopathy and a further distinction is made between primary and secondary MMD. Clinical presentation depends on age and population, with hemorrhage and ischemic infarcts in particular leading to severe neurolo...
Source: Translational Stroke Research - Category: Neurology Source Type: research
Brain Struct Funct. 2022 Jan 18. doi: 10.1007/s00429-021-02442-1. Online ahead of print.ABSTRACTThe medial temporal lobe (MTL) is a set of interconnected brain regions that have been shown to play a central role in behavior as well as in neurological disease. Recent studies using resting-state functional magnetic resonance imaging (rsfMRI) have attempted to understand the MTL in terms of its functional connectivity with the rest of the brain. However, the exact characterization of the whole-brain networks that co-activate with the MTL as well as how the various sub-regions of the MTL are associated with these networks rema...
Source: Brain Structure and Function - Category: Neuroscience Authors: Source Type: research
Mater Sci Eng C Mater Biol Appl. 2022 Jan 4:112626. doi: 10.1016/j.msec.2021.112626. Online ahead of print.ABSTRACTHIV and hepatitis B are two of the most prevalent viruses globally, and despite readily available preventive treatments unforgiving treatment regimens still exist, such as daily doses of medicine that are challenging to maintain especially in poorer countries. More advanced and longer-lasting delivery vehicles can potentially overcome this problem by reducing maintenance requirements and significantly increase access to medicine. Here, we designed a technology to control the delivery of an antiviral drug over ...
Source: Appl Human Sci - Category: Physiology Authors: Source Type: research
Eye, Published online: 18 January 2022; doi:10.1038/s41433-021-01910-6Feasibility of standalone antitubercular therapy for retinal vasculitis
Source: Eye - Category: Opthalmology Authors: Source Type: research
ConclusionsThe results of this review show that SSRI use was associated with a 34% lower risk of HCC, which tend to be dose dependent. Further prospective studies are warranted to confirm these observations across the spectrum of chronic liver disease and hepatitis infection.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsAutosomal dominant TLR3 deficiency may underlie severe EV71 infection with encephalitis. Human TLR3 immunity is essential to protect the central nervous system against HSV-1 and EV71. Children with severe EV71 infections, such as encephalitis in particular, should be tested for inborn errors of TLR3 immunity.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
This study provides a basis for further study of the shrimp intestinal antiviral immune response and for the formulation of effective new strategies for the prevention and treatment of DIV1 infection.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
More News: Angiography | Borrelia | Brain | Cold Sores | Hepatitis | Hepatitis B | Hepatitis C | Herpes | Infectious Diseases | Lyme Disease | MRI Scan | Neurology | Vasculitis | Vitamin A