Infectious mimics of rheumatoid arthritis

Best Pract Res Clin Rheumatol. 2021 Dec 31:101736. doi: 10.1016/j.berh.2021.101736. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) can have various infectious mimics. As immunosuppressive agents used in treatment can aggravate the underlying infections, correct diagnosis of RA and ruling out infections is important. Numerous viral infections (Parvovirus B19, Hepatitis B, Hepatitis C, Chikungunya and other alphaviruses, human immunodeficiency virus (HIV) and various other viruses), mycobacterial infections (Poncet's disease, tubercular septic arthritis, and leprosy), bacterial arthritis, brucellosis and Lyme disease are among common infections that mimic RA. Widespread travel and tourism, especially to exotic areas, high risk sexual behavior and widespread use of immunosuppressive and chemotherapeutic agents has led to numerous outbreaks of infections in areas where these infections were never reported before. Hence, rheumatologists all over the world should be familiar with musculoskeletal manifestations of infections. History of travel, comorbid fever, skin rash, genital ulcers, urethral discharge, the consumption of unpasteurized milk, lymphadenopathy, tenosynovitis, low platelet count, and positive Mantoux test can offer potential diagnostic clues. Serological testing, cultures, specific radiological signs and deoxyribonucleic Acid (DNA) amplification techniques often aid in diagnosis. Treatment mainly consists of antimicrobial agents, analgesics, and nonsteroidal...
Source: Cell Research - Category: Cytology Authors: Source Type: research

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Discussion: Private physicians reusing intravenous drip sets to treat outpatients seen in private practice were responsible for this HIV epidemic. Mapping and regulation of private practitioners were suggested.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Rapid Communication Source Type: research
HANGZHOU and SHAOXING, China, Jan. 17, 2022. Ascletis Pharma Inc. announced today the Investigational New Drug (IND) application approval by U.S. Food and Drug Administration (FDA) and initiation of global development of ASC22 (Envafolimab), a...
Source: Drugs.com - Clinical Trials - Category: Pharmaceuticals Source Type: clinical trials
EXCLUSIVE: Some 6,519 out of 6,790 neighbourhoods (96 per cent) around the UK recorded a fall in infections in the week to January 11, according to the UK Health Security Agency (UKHSA).
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Vaccine. 2022 Jan 13:S0264-410X(22)00006-8. doi: 10.1016/j.vaccine.2022.01.003. Online ahead of print.ABSTRACTVaccination guidelines for dogs and cats indicate that core vaccines (for dogs, rabies, distemper, adenovirus, parvovirus; for cats, feline parvovirus, herpes virus-1, calicivirus) are essential to maintain health, and that non-core vaccines be administered according to a clinician's assessment of a pet's risk of exposure and susceptibility to infection. A reliance on individual risk assessment introduces the potential for between-practice inconsistencies in non-core vaccine recommendations. A study was initiated t...
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research
This study highlights the pharmacogenetic recommendations for dermatology therapies that have the strongest evidence at this time, highlighting those that have been incorporated in clinical practice guides. Pharmacogenetic clinical guidelines for multiple squamous cell carcinoma and psoriasis vulgaris were found in this investigation. Here, for multiple squamous cell carcinoma trichohyalin-like 1 (TCHHL1), 5-fluorouracil (5-FU) 0.5% is recommended. Along with that dapsone, Valosin-containing protein can be recommended for treating the psoriasis vulgaris. We made some clinical trials over the two diseases, and from the resu...
Source: Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research
Am J Transl Res. 2021 Dec 15;13(12):13981-13992. eCollection 2021.ABSTRACTThe clinical course of Pneumocystis pneumonia in liver transplant recipients has not been well investigated. Therefore, we collected and analyzed the clinical, epidemiological, and molecular data from patients with Pneumocystis pneumonia as well as paired controls (Chinese Clinical Trial Registry, ChiCTR2100046028; www.chictr.org.cn). There were a total of ten patients diagnosed with Pneumocystis pneumonia containing prospectively included six patients and retrospectively collected four patients, of which seven were transferred to the surgical intens...
Source: Cell Research - Category: Cytology Authors: Source Type: research
Biocontrol Sci. 2021;26(4):221-224. doi: 10.4265/bio.26.221.ABSTRACT Two Bacillus strains were screened and identified using 16S rRNA gene sequencing the phenotypic tests, and then characterized in vitro for the probiotic characteristics. They were able to tolerate pH 2.5 for 2.5 h, following 0.3% bile salts and 0.1% pancreatin treatment for 5 h. They exhibited good ability to attach to intestinal epithelial cells and were susceptible to most of the antibiotics and being killed by several. Further and more important, they showed good proteolytic activity to food protein as gelatin and milk, with even higher activity than t...
Source: Biocontrol Science - Category: Microbiology Authors: Source Type: research
Am J Transl Res. 2021 Dec 15;13(12):14186-14194. eCollection 2021.ABSTRACTOBJECTIVE: To explore the incidence, distribution characteristics and related symptoms of gastroesophageal reflux disease (GERD) as well as its related risk factors in Kashgar, Xinjiang.METHODS: From March 2020 to October 2020, a questionnaire survey was conducted among 5,080 permanent residents aged 18-80 years in Kashgar using cluster sampling and stratified sampling methods. The content included basic information, accompanying symptoms and diseases, living, customs and eating habits, and Gastroesophageal Reflux Disease Questionnaire score, etc. Re...
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
Am J Transl Res. 2021 Dec 15;13(12):14168-14175. eCollection 2021.ABSTRACTOBJECTIVE: This research was designed to probe into the influences of natural shoulder delivery combined with free position delivery on pregnant outcome and genital tract of puerperants.METHODS: Totally 128 puerperants who gave birth in our hospital from May 2018 to November 2019 were selected as the research objects. Among them, 66 in traditional position combined with traditional shoulder delivery were assigned to a conventional group (CG), and 62 in free position combined with natural shoulder delivery were assigned to a research group (RG). Their...
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
Am J Transl Res. 2021 Dec 15;13(12):13981-13992. eCollection 2021.ABSTRACTThe clinical course of Pneumocystis pneumonia in liver transplant recipients has not been well investigated. Therefore, we collected and analyzed the clinical, epidemiological, and molecular data from patients with Pneumocystis pneumonia as well as paired controls (Chinese Clinical Trial Registry, ChiCTR2100046028; www.chictr.org.cn). There were a total of ten patients diagnosed with Pneumocystis pneumonia containing prospectively included six patients and retrospectively collected four patients, of which seven were transferred to the surgical intens...
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
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