Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators

Cell Mol Neurobiol. 2022 Jan 3. doi: 10.1007/s10571-021-01185-1. Online ahead of print.ABSTRACTNMDA receptors play an important physiological role in regulating synaptic plasticity, learning and memory. GluN2A subunits are the most abundant functional subunits of NMDA receptors expressed in mature brain, and their dysfunction is related to various neurological diseases. According to subunit composition, GluN2A-containing NMDA receptors can be divided into two types: diheteromeric and triheteromeric receptors. In this review, the expression, functional and pharmacological properties of different kinds of GluN2A-containing NMDA receptors as well as selective GluN2A regulators were described to further understand this type of NMDA receptors.PMID:34978648 | DOI:10.1007/s10571-021-01185-1
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Source Type: research