Hysteroscopic Endometrial Resection in Symptomatic Tamoxifen Treated Women for Breast Cancer Can Provide Both Definitive Diagnosis and Effective Long-term Therapy

J Obstet Gynaecol Can. 2021 Dec 29:S1701-2163(21)00939-7. doi: 10.1016/j.jogc.2021.12.007. Online ahead of print.ABSTRACTWe evaluated resectoscopic surgery for definitive diagnosis and long-term therapy in 16 symptomatic tamoxifen-treated women with breast cancer who presented with abnormal uterine bleeding and/or intrauterine anomalies. Seven pre-menopausal women had benign pre- and post-operative endometrial biopsy, and 4 had benign polyps. At a median of 7 years of follow-up (range 2-8), all remained amenorrheic. Of 9 post-menopausal women, pre-operative biopsy was inadequate in 4, benign endometrium was found in 4, and non-atypical endometrial hyperplasia was found in 1. Post-operatively, all had benign pathology, 8 having polyp and 1 leiomyoma. At a median follow-up of 7 years (range 2-13), all were amenorrheic, with no recurrence of breast cancer or uterine pathology.PMID:34973434 | DOI:10.1016/j.jogc.2021.12.007
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Authors: Source Type: research