A short term mouse model that reproduces the immunopathological features of rhinovirus induced exacerbation of COPD
Viral exacerbations of chronic obstructive pulmonary disease (COPD), commonly caused by rhinovirus (RV) infection, are poorly controlled by current therapies. This is due to a lack of understanding of the underlying immunopathological mechanisms. Human studies have identified a number of key immune responses that are associated with RV-induced exacerbations including neutrophilic inflammation, expression of inflammatory cytokines and deficiencies in innate anti-viral interferon. Animal models of COPD exacerbation are required to determine the contribution of these responses to disease pathogenesis. We aimed to develop a short-term mouse model that reproduced the hallmark features of RV-induced exacerbation of COPD. Evaluation of complex protocols involving multiple dose elastase and lipopolysaccharide administration combined with RV1B infection showed suppression rather than enhancement of inflammatory parameters compared to control mice infected with RV1B alone. Therefore, these approaches did not accurately model the enhanced inflammation associated with RV infection in patients with COPD compared to healthy subjects. In contrast, a single elastase treatment followed by RV infection led to heightened airway neutrophilic and lymphocytic inflammation, increased expression of TNF-α, CXCL10/IP-10 and CCL5/RANTES, mucus hyper-secretion and preliminary evidence for increased airway hyper-responsiveness compared to mice treated with elastase or RV infection alone. In summary...
Authors: PMID: 31599654 [PubMed - as supplied by publisher]
Publication date: Available online 10 October 2019Source: Heart &LungAuthor(s): Shashank Shekar Singh, Anup Bhat, Aswini Kumar Mohapatra, Mohan K Manu, K VaishaliAbstractBackgroundReaction time is one of the components of functional balance and could contribute to balance impairment. Information regarding this relationship is scant among Chronic Obstructive Pulmonary Disease (COPD) participants.ObjectivesTo compare stepping reaction time between participants with COPD and age; gender-matched healthy individuals to find out whether reaction time in COPD population is affected.MethodsThis cross-sectional study included 4...
Conditions: Chronic Obstructive Pulmonary Disease; Respiratory Failure Intervention: Other: Fixed-dose compared to variable oxygen flow supplementation during walking Sponsors: Hvidovre University Hospital; Region Örebro County; Aalborg University Hospital; Danmarks Lungeforening Not yet recruiting
Conclusions: As RHP roles continue to evolve, consideration should be given to the ways in which RHPs can contribute to improving the quality of care for patients with advanced respiratory disease. Building collaborations with RHPs, palliative care, and other existing health programs can ensure high quality of care. Creating and taking advantage of learning opportunities to build skills and comfort in using a palliative approach will benefit respiratory patients. PMID: 31595226 [PubMed]
Abstract Introduction: Few investigations have related objective assessments of indoor air pollutants to respiratory health in farmers, in spite of the many rural environmental hazards to which they are exposed. Chemical air pollution has been particularly neglected. Objective: We investigated the relationships of indoor exposure to particulate matter (PM) and volatile organic compounds (VOCs) to respiratory health in farmers. Methods: Nineteen VOCs (5 families) and PM (from ultrafine to total suspended particles (TSP)) were objectively assessed in dwellings and workplaces in 109 French farmers du...
This study demonstrates the value of incorporating youth perspectives in environmental health research, and that photovoice was a valuable approach to elicit such perspectives.
Conditions: Exacerbation Copd; Bronchiectasis; Lung Function Decreased Interventions: Drug: Roflumilast; Drug: Placebo Sponsor: Prince of Songkla University Completed