Therapeutic Potential of Nitric Oxide releasing Selective Estrogen Receptor Modulators (NO-SERMs) in Malignant Melanoma

Malignant melanoma has a steadily increasing incidence, but treatment options are still limited and prognosis for patients, especially for men, is poor. To investigate whether targeting estrogen receptor (ER) signaling is a valid therapeutic approach, we retrospectively analyzed ER gene expression profiles in 448 melanoma patients. High ER α gene expression was associated with improved overall survival (HR=0.881; 95% Cl=0.793-0.979, p=0.018) and increased with tumor stage, while ERβ gene expression did not change with tumor progression.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research