Radiation therapy promotes hepatocellular carcinoma immune-cloaking via PD-L1 upregulation induced by cGAS-STING activation

Radiotherapy (RT) is one of the main treatments for patients with unresectable hepatocellular carcinoma (HCC). Emerging evidence indicates that the cGAS-STING pathway is crucial in RT-induced antitumor immune responses. Here, we discovered that activation of the cancer cell-intrinsic cGAS-STING pathway mediated immune-cloaking after RT-induced DNA damage.

Source: International Journal of Radiation Oncology * Biology * Physics - January 2, 2022 Category: Radiology Authors: Shi-Suo Du, Gen-Wen Chen, Ping Yang, Yi-Xing Chen, Yong Hu, Qian-Qian Zhao, Yang Zhang, Rong Liu, Dan-Xue Zheng, Jian Zhou, Jia Fan, Zhao-Chong Zeng Tags: Biology Contribution Source Type: research