Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease

CONCLUSIONS: In obese patients, the best-performing fibrosis biomarkers are ADAPT and the inexpensive FIB-4, which are unaffected by BMI. The widely used NFS loses specificity in obese individuals, which may be corrected with BMI-adjusted cut-offs.PMID:34971370 | DOI:10.1210/clinem/dgab933

Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2021 Category: Endocrinology Authors: Sami Qadri Noora Ahlholm Ida L ønsmann Paola Pellegrini Anni Poikola Panu K Luukkonen Kimmo Porthan Anne Juuti Henna Sammalkorpi Anne K Penttil ä Roberta D'Ambrosio Giorgio Soardo Diana J Leeming Morten Karsdal Johanna Arola Stergios Kechagias Serena Pe Source Type: research