Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model

This study unveils a novel mechanism by which HNSCC evades NK cell killing, and sheds light on designing novel anti-HNSCC immunotherapy targeting Bat3 and Tim-3 signaling.PMID:34968777 | DOI:10.1016/j.imbio.2021.152127

Source: Immunobiology - December 30, 2021 Category: Allergy & Immunology Authors: Jiyong Yang Jun Xiang Meiling Zhu Yuman Zhao Lei Zhou Binbin Hu Cheng Wang Source Type: research