Bradykinin-mediated estrogen-dependent depressor response by direct activation of female-specific distribution of myelinated Ah-type baroreceptor neurons in rats

CONCLUSION: These datasets have demonstrated for the first time that bradykinin mediates direct activation of baroreflex afferent function to trigger estrogen-dependent depressor response, which is due mainly to the direct activation/neuroexcitation of female-specific myelinated Ah-type baroreceptor neurons leading to a sexual dimorphism in parasympathetic domination of blood pressure regulation via activation of B2 R/B1 R expression in baroreflex afferent pathway.PMID:34964272 | DOI:10.1111/cns.13792

Source: CNS Neuroscience and Therapeutics - December 29, 2021 Category: Neuroscience Authors: Ke-Xin Li Yan Feng Xiong-Xiong Fan Xun Sun Ying Li Di Wu Li Liu Chang-Peng Cui Xue Xiong Hu-Die Li Meng Zhou Hai-Lan Ma Yang Liu Rong Zhang Bai-Yan Li Source Type: research