Effect of major components of Tripterygium wilfordii Hook. f on the uptake function of organic anion transporting polypeptide 1B1

In conclusion, co- and pre-incubation of the tested TWHF components inhibited OATP1B1 activity in different manners. Although co-incubation of WFG and WFR did not seem to directly compete with the substrates, pre-incubation of these alkaloids may alter the substrate-transporter interaction.PMID:34958783 | DOI:10.1016/j.taap.2021.115848

Source: Toxicology and Applied Pharmacology - December 27, 2021 Category: Toxicology Authors: Jieru Chen Yuanping Xue Xiaoyu Shuai Chunxu Ni Zihui Fang Ling Ye Mei Hong Source Type: research