Glyoxal induces senescence in human keratinocytes through oxidative stress and activation of the AKT/FOXO3a/p27KIP1 pathway

Senescence is a well-characterized cellular state associated with specific markers such as permanent cell proliferation arrest, and the secretion of messenger molecules by cells expressing the Senescence-Associated Secretory Phenotype (SASP). The SASP composition depends on many factors such as the cell type or the nature of the stress that induces senescence. Since the skin constitutes a barrier with the external environment, it is particularly subjected to different types of stresses, and consequently prone to premature cellular aging.

Source: Journal of Investigative Dermatology - December 28, 2021 Category: Dermatology Authors: Rym Halkoum, Virginie Salnot, Christophe Capallere, Christelle Plaza, Aurore L ’Honoré, Karl Pays, Bertrand Friguet, Carine Nizard, Isabelle Petropoulos Tags: Original Article Source Type: research