Interferon-gamma induced APOBEC3B contributes to Merkel cell polyomavirus genome mutagenesis in Merkel cell carcinoma.
Merkel cell polyomavirus (MCPyV) is the causative agent of an aggressive skin tumor, Merkel cell carcinoma (MCC). The viral genome is integrated into the tumor genome and harbors nonsense mutations in the helicase domain of large T antigen (LTAg). However, the molecular mechanisms by which the viral genome gains the tumor-specific mutations remain to be elucidated. Focusing on host cytosine deaminases APOBEC3s (A3s), we find that A3A, A3B, or A3G introduces A3-specific mutations into episomal MCPyV genomes in MCPyV-replicating 293-derivative cells.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Lusheng Que, Yingfang Li, Teruki Dainichi, Iwao Kukimoto, Tomoaki Nishiyama, Yuri Nakano, Kaori Shima, Tadaki Suzuki, Yuko Sato, Shinichi Horike, Hideki Aizaki, Koichi Watashi, Takanobu Kato, Hussein H. Aly, Noriyuki Watanabe, Kenji Kabashima, Kousho Waka Tags: Original Article Source Type: research