Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor

Conclusion
Expression of NPP1 and 5'-nucleotidase by VICs promotes the mineralization of the aortic valve through A2aR and a cAMP/PKA/CREB pathway.

Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Mahmut, A., Boulanger, M.-C., Bouchareb, R., Hadji, F., Mathieu, P. Tags: Vascular biology Source Type: research