Early subcellular Ca2+ remodelling and increased propensity for Ca2+ alternans in left atrial myocytes from hypertensive rats

Conclusions
In SHR, hypertension induces early subcellular LA myocyte Ca2+ remodelling during compensated LV hypertrophy. In basal conditions, atrial myocyte CaTs are not changed. At increased stimulation frequency, however, SHR atrial myocytes become more prone to arrhythmogenic Ca2+ alternans, suggesting a link between hypertension, atrial Ca2+ homeostasis, and development of atrial tachyarrhythmias.

Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Pluteanu, F., Hess, J., Plackic, J., Nikonova, Y., Preisenberger, J., Bukowska, A., Schotten, U., Rinne, A., Kienitz, M.-C., Schafer, M. K.- H., Weihe, E., Goette, A., Kockskamper, J. Tags: Cardiac biology and remodelling Source Type: research