Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves

Conclusion Cardiac defects in mutants for Robo or Slit range from membranous ventricular septum defects to bicuspid aortic valves. These ligands and receptors have unique functions during development of specific cardiac cushion derivatives, and the Slit-Robo signalling pathway likely enforces its role by regulating Notch signalling, making these mutants a valuable new model to study cardiac valve formation.

http://cardiovascres.oxfordjournals.org/cgi/content/short/106/1/55?rss=1

Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Mommersteeg, M. T. M., Yeh, M. L., Parnavelas, J. G., Andrews, W. D. Tags: Cardiac biology and remodelling Source Type: research