Fibroblast growth factor 21 protects the heart from oxidative stress

Conclusion
Our data indicate that Fgf21 regulates genes involved in antioxidant pathways in an autocrine manner, thus preventing ROS production in cardiac cells. Therefore, Fgf21 acts as an antioxidant factor in the heart, preventing induction of pro-oxidative pathways by inflammatory or hypertrophic conditions.

Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Planavila, A., Redondo-Angulo, I., Ribas, F., Garrabou, G., Casademont, J., Giralt, M., Villarroya, F. Tags: Cardiac biology and remodelling Source Type: research