Cancers, Vol. 14, Pages 98: The Increasing Prognostic and Predictive Roles of the Tumor Primary Chemosensitivity Assessed by CA-125 Elimination Rate Constant K (KELIM) in Ovarian Cancer: A Narrative Review

Cancers, Vol. 14, Pages 98: The Increasing Prognostic and Predictive Roles of the Tumor Primary Chemosensitivity Assessed by CA-125 Elimination Rate Constant K (KELIM) in Ovarian Cancer: A Narrative Review Cancers doi: 10.3390/cancers14010098 Authors: Ambroise Lauby Olivier Colomban Pauline Corbaux Julien Peron Lilian Van Wagensveld Witold Gertych Naoual Bakrin Pierre Descargues Jonathan Lopez Vahan Kepenekian Olivier Glehen Charles Andre Philip Mojgan Devouassoux-Shisheboran Michel Tod Gilles Freyer Benoit You Ovarian cancer is the gynecological cancer with the worst prognosis and the highest mortality rate because 75% of patients are diagnosed with advanced stage III–IV disease. About 50% of patients are now treated with neoadjuvant chemotherapy followed by interval debulking surgery (IDS). In that context, there is a need for accurate predictors of tumor primary chemosensitivity, as it may impact the feasibility of subsequent IDS. Across seven studies with more than 12,000 patients, including six large randomized clinical trials and a national cancer registry, along with a mega-analysis database with 5842 patients, the modeled CA-125 ELIMination rate constant K (KELIM), the calculation of which is based on the longitudinal kinetics during the first three cycles of platinum-based chemotherapy, was shown to be a reproducible indicator of tumor intrinsic chemosensitivity. Indeed, KELIM is strongly associated with the likelih...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research