The association between diversity and composition of vaginal microbiota of Iranian women with and without human papillomavirus infection
In this study, 69 vaginal samples with and without manifestation of HPV were obtained from women referring to a gynecology clinic and extracted DNA was introduced to real-time PCR looking for the HPV serotypes and bacterial load by using bacterial 16S rRNA gene.
Results:
Out of 64 samples, 16 isolates were normal, 13 isolates were clearance or HPV-negative, and 16 isolates were persistence or HPV-positive. Lactobacillus spp. is the predominant vaginal microbiota in normal women and its count became lower at HPV-negative and finally became zero at HPV-positive group. We could approve a significant increase in the colony count of Bacteroides, and Bifidobacteria in HPV 16 group. The statistical analysis did not show any significant association between the frequency or presence of each bacterium and the types of cervical cell abnormalities (P value
Source: Reviews in Medical Microbiology - Category: Microbiology Tags: MICROBIOLOGY Source Type: research
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