Platelet Phagocytosis via P ‐selectin Glycoprotein Ligand 1 and Accumulation of Microparticles in Systemic Sclerosis

ConclusionThe clearance of activated platelets via PSGL-1 limits the undesirable effects of MP-elicited neutrophil activation. This balance is disrupted in patients with SSc. Its reconstitution might curb vascular inflammation and prevent fibrosis.

Source: Arthritis and Rheumatology - December 24, 2021 Category: Rheumatology Authors: Angelo A. Manfredi, Giuseppe A. Ramirez, Cosmo Godino, Annalisa Capobianco, Antonella Monno, Stefano Franchini, Enrico Tombetti, Sara Corradetti, J örg H. W. Distler, Marco E. Bianchi, Patrizia Rovere‐Querini, Norma Maugeri Tags: Full Length Source Type: research