N2-polarized Neutrophils Reduce Inflammation in Rosacea by Regulating Vascular Factors and Proliferation of CD4+ T Cells

This study explores the biological function of neutrophils and their underlying mechanism in rosacea. A rosacea-like mouse model was established to explore the polarization of neutrophils. RNA sequencing was used to investigate the underlying mechanisms. Our results show that neutrophils partly switched to N2 phenotypes in both rosacea patients and rosacea-like mouse models. The rosacea-like phenotype and inflammation in both a genetic mutation (Genista mice) and the Gr-1 antibody-induced neutropenia mice were significantly aggravated compared to the control groups.

Source: Journal of Investigative Dermatology - December 21, 2021 Category: Dermatology Authors: Zhixiang Zhao, Tangxiele Liu, Yinming Liang, Weiwei Cui, Dong Li, Guohong Zhang, Zhili Deng, Mengting Chen, Ke Sha, Wenqin Xiao, Hongfu Xie, Ji Li Tags: Original Article Source Type: research