Effect of Clonally Expanded PD ‐1highCXCR5–CD4+ Peripheral T Helper Cells on B Cell Differentiation in the Joints of Patients With Antinuclear Antibody–Positive Juvenile Idiopathic Arthritis

ConclusionClonally expanded CD4+ Tph cells accumulate in the joints of ANA-positive JIA patients and, in particular, promote CD21low/ –CD11c+ DN B cell differentiation. The expansion of Tph cells and DN B cells might reflect the autoimmune response in the joints of ANA-positive JIA patients.

https://onlinelibrary.wiley.com/doi/10.1002/art.41913?af=R

Source: Arthritis and Rheumatology - December 16, 2021 Category: Rheumatology Authors: Jonas Fischer, Johannes Dirks, Julia Klaussner, Gabriele Haase, Annette Holl ‐Wieden, Christine Hofmann, Stephan Hackenberg, Hermann Girschick, Henner Morbach Tags: Full Length Source Type: research