Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice

ConclusionOur results in a mouse model of OA demonstrate that IFT88 performs a chondroprotective role in articular cartilage by controlling the calcification of cartilage via maintenance of a threshold of Hh signaling during physiologic loading.

Source: Arthritis and Rheumatology - December 16, 2021 Category: Rheumatology Authors: Clarissa R. Coveney, Linyi Zhu, Jadwiga Miotla ‐Zarebska, Bryony Stott, Ida Parisi, Vicky Batchelor, Claudia Duarte, Emer Chang, Eleanor McSorley, Tonia L. Vincent, Angus K. T. Wann Tags: Full Length Source Type: research