Antimicrobial late cornified envelope (LCE) proteins: the psoriasis risk factor LCE3B/C-del affects microbiota composition

Late cornified envelope (LCE) proteins are predominantly expressed in the skin and other cornified epithelia. Based on sequence similarity, this eighteen-member homologous gene family has been subdivided into six groups. The LCE3 proteins have been the focus of dermatological research, as the combined deletion of LCE3B and LCE3C genes (LCE3B/C-del) is a risk factor for psoriasis. We previously reported that LCE3B/C-del increases expression of the LCE3A gene and that LCE3 proteins exert antibacterial activity.

Source: Journal of Investigative Dermatology - December 20, 2021 Category: Dermatology Authors: Hanna Niehues, Danique A. van der Krieken, Thomas H.A. Ederveen, Patrick A.M. Jansen, Laura van Niftrik, Rob Mesman, Mihai G. Netea, Jos P.H. Smits, Joost Schalkwijk, Ellen H. van den Bogaard, Patrick L.J.M. Zeeuwen Tags: Original Article Source Type: research