Additive Effects of Genetic Interleukin-6 Signaling Downregulation and Low-Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2 ×2 Factorial Mendelian Randomization Analysis

Conclusions Genetically downregulated IL-6 signaling and genetically lowered LDL-C are associated with additively lower lifetime risk of cardiovascular disease. Future trials should explore combined IL-6 inhibition and LDL-C lowering treatments for cardiovascular prevention.PMID:34927447 | DOI:10.1161/JAHA.121.023277

Source: Atherosclerosis - December 20, 2021 Category: Cardiology Authors: Marios K Georgakis Rainer Malik Stephen Burgess Martin Dichgans Source Type: research