Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins

CONCLUSIONS: Triptonide effectively suppressed TNBC cell tumorigenesis, vasculogenic mimicry, and strongly inhibited the metastasis of TNBC via degradation of Twist1 and Notch1 oncoproteins, downregulation of metastatic and angiogenic gene expression, and reduction of NF-κB signaling pathway. Our findings provide a new strategy for treating highly lethal TNBC and offer a potential new drug candidate for combatting this aggressive disease.PMID:34922602 | DOI:10.1186/s13058-021-01488-7

Source: Cell Research - December 19, 2021 Category: Cytology Authors: Mengli Zhang Mei Meng Yuxi Liu Jindan Qi Zhe Zhao Yingnan Qiao Yanxing Hu Wei Lu Zhou Zhou Peng Xu Quansheng Zhou Source Type: research