PTEN Loss and PD-L1 Expression of Different Histological Patterns of Prostate Cancer

CONCLUSIONS: In conclusion, in our cohort of consecutive unselected cases of prostatic carcinoma, we observed the highest PTEN loss rate in the GG4 cribriform and glomeruloid pattern and the highest PD-L1 expression rate in the GG5 and GG4 irregular patterns. These results may predict molecular differences between different histological patterns in PCa and may be used to inform a treatment decision. Future studies should investigate these differences between histological patterns of PCa to predict response to immunotherapy in larger cohorts.PMID:34922209 | DOI:10.1016/j.prp.2021.153738

Source: Cell Research - December 18, 2021 Category: Cytology Authors: Gozde Kir Gozde Ecem Cecikoglu Zeynep Cagla Olgun Huseyin Ozgur Kazan Asif Yildirim Source Type: research