The Effects of Baseline Impaired Global Cognitive Function on the Efficacy and Cognitive Effects of Electroconvulsive Therapy in Geriatric Patients: A Retrospective Cohort Study

Depression is common among elderly patients, and is associated with significant physical impairment1 and elevated risk of suicide.2 While antidepressants remain the mainstay of treatment for depression across the age span, geriatric patients have less physical reserve than younger patients and more significant medical comorbidities, which may limit the effectiveness of medication treatment and increase urgency for rapid relief of depressive symptoms.3 The prospective Prolonging Remission in Depressed Elderly (PRIDE) trial demonstrated that Electroconvulsive therapy (ECT) using right unilateral ultrabrief pulse stimulus provides rapid relief of symptoms in older adults with depression,4 and, in current clinical practice in the United States, ECT is used at higher rates in older patients relative to younger ones.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Source Type: research