Distinct Microbial Communities in Dilated Cardiomyopathy Explanted Hearts Are Associated With Different Myocardial Rejection Outcomes

CONCLUSIONS: This initial study investigating on infectious agents and inflammation in the IDCM explanted hearts showed that the association between M. pneumoniae and hepatitis B core was associated with a worse outcome after HT, represented by MR and PMR, suggesting that different IDCM microbial communities may be contributing to post-transplant myocardial rejection.PMID:34912727 | PMC:PMC8668412 | DOI:10.3389/fcimb.2021.732276
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research

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T cell polyfunctionality is a hallmark of protective immunity against pathogens and cancer, yet the molecular mechanism governing it remains mostly elusive. We found that canonical Wnt agonists inhibited human memory CD8+ T cell differentiation while simultaneously promoting the generation of highly polyfunctional cells. Downstream effects of Wnt activation persisted after removal of the drug, and T cells remained polyfunctional following subsequent cell division, indicating the effect is epigenetically regulated. Wnt activation induced a gene expression pattern that is enriched with stem cell–specific gene signature...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Tertiary lymphoid tissues (TLTs) facilitate local T and B cell interactions in chronically inflamed organs. However, the cells and molecular pathways that govern TLT formation are poorly defined. Here, we identified TNF superfamily CD153/CD30 signaling between 2 unique age-dependent lymphocyte subpopulations, CD153+PD-1+CD4+ senescence-associated T (SAT) cells and CD30+T-bet+ age-associated B cells (ABCs), as a driver for TLT expansion. SAT cells, which produced ABC-inducing factors IL-21 and IFN-γ, and ABCs progressively accumulated within TLTs in aged kidneys after injury. Notably, in kidney injury models, CD153 or...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
TUESDAY, Jan. 18, 2022 -- Real-world data show steady improvement in overall survival (OS) for patients with Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) who experienced relapse after allogeneic hematopoietic cell transplantation...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
HIV-positive kidney- and liver-transplant patients can expect good long-term outcomes following the transplant, comparable with those of matched HIV-negative peers, according to a new study.Reuters Health Information
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Transplantation News Source Type: news
An observational, multicenter Chinese study showed that diabetes plus low HDL-C significantly links with a nearly doubled peritonitis rate in patients on peritoneal dialysis.First Look
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Diabetes & Endocrinology News Source Type: news
Funding Opportunity RFA-AI-22-002 from the NIH Guide for Grants and Contracts. This purpose of this RFA is to solicit applications for the Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG), a multi-center, cooperative program dedicated to developing, optimizing, and evaluating approaches to induce and maintain immune tolerance to allogeneic transplants in nonhuman primate (NHP) models. The over-arching goal is to facilitate clinical translation of safe and effective tolerance-induction protocols for long-term graft survival.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Conclusion: Our data indicate that the expression of the glycolytic phenotype of metabolic markers, especially GLUT1 and MCT4, correlates with a more severe course of HCC occurring in NASH patients.Pathobiology
Source: Pathobiology - Category: Pathology Source Type: research
Patients treated with immune checkpoint inhibitors may realize a greater risk for developing hyponatremia and other electrolyte disorders. How common are these events?Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
CONCLUSION: It is concluded that co-culture of MSCs with Molt-4 cells could be involved in the changing the methylation status of hTERT gene promoter, cell cycle and hTERT protein expression; it could potentially beneficial for further investigations regarding the cell transplantation and cell-based therapy.PMID:35040412 | DOI:10.2174/1566524022666220118103136
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
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