The iPSC perspective on schizophrenia

Trends Neurosci. 2021 Dec 4:S0166-2236(21)00229-0. doi: 10.1016/j.tins.2021.11.002. Online ahead of print.ABSTRACTOver a decade of schizophrenia research using human induced pluripotent stem cell (iPSC)-derived neural models has provided substantial data describing neurobiological characteristics of the disorder in vitro. Simultaneously, translation of the results into general mechanistic concepts underlying schizophrenia pathophysiology has been trailing behind. Given that modeling brain function using cell cultures is challenging, the gap between the in vitro models and schizophrenia as a clinical disorder has remained wide. In this review, we highlight reproducible findings and emerging trends in recent schizophrenia-related iPSC studies. We illuminate the relevance of the results in the context of human brain development, with a focus on processes coinciding with critical developmental periods for schizophrenia.PMID:34876311 | DOI:10.1016/j.tins.2021.11.002

Source: Trends in Neurosciences - December 8, 2021 Category: Neuroscience Authors: Noora R äsänen Jari Tiihonen Marja Koskuvi Šárka Lehtonen Jari Koistinaho Source Type: research