Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4d ⁺ Antibody-Mediated Rejection in Kidney Transplant Recipients
CONCLUSIONS C1q⁺/C3d⁺ dnDSA were associated with C4d⁺ AMR and high-IgG MFI. Our data call into question the predictive utility of C1q/C3d-binding assays in identifying KTx recipients at risk of allograft failure. In conclusion, IgG MFI is sufficient for clinical management, and the C1q/C3d-assays with added cost do not provide any additional information.PMID:34848674 | DOI:10.12659/AOT.934175
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Vasishta S Tatapudi Dessislava Kopchaliiska Gilberto J da Gente Owen F Buenaventura Manpreet Singh Zoltan Laszik Deborah B Adey Raja Rajalingam Source Type: research
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