Mechanisms and pathophysiological significance of eryptosis, the suicidal erythrocyte death
Publication date: Available online 27 January 2015 Source:Seminars in Cell & Developmental Biology Author(s): Elisabeth Lang , Florian Lang Eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and cell membrane scrambling, is stimulated by Ca2+ entry through Ca2+-permeable, PGE2-activated cation channels, by ceramide, caspases, calpain, complement, hyperosmotic shock, energy depletion, oxidative stress, and deranged activity of several kinases (e.g. AMPK, GK, PAK2, CK1α, JAK3, PKC, p38-MAPK). Eryptosis is triggered by intoxication, malignancy, hepatic failure, diabetes, chronic renal insufficiency, hemolytic uremic syndrome, dehydration, phosphate depletion, fever, sepsis, mycoplasma infection, malaria, iron deficiency, sickle cell anemia, thalassemia, glucose 6-phosphate dehydrogenase deficiency, and Wilson's disease. Eryptosis may precede and protect against hemolysis but by the same token result in anemia and deranged microcirculation.
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
More News: Anemia | Biology | Cancer & Oncology | Cytology | Depression | Diabetes | Endocrinology | G6PD | Hemolytic Uremic Syndrome (HUS) | Malaria | Sickle Cell Anemia | Suicide | Wilson's Disease