Mixed Motor Disorder: Essential Tremor Families With Heterogeneous Motor Phenomenology

We present 4 families, including 14 affected individuals, among whom assigned diagnoses were ET, PD, ET + PD, and ET + dystonia. In those with ET and another movement disorder, the predominant and earliest phenotype was ET. Discussion There are assortments of these 3 involuntary motor disorders, ET, dystonia, and PD, both within individuals and in different individuals within ET families. This observation has mechanistic implications. Furthermore, we believe that the concept of the mixed motor disorder should enter into and inform the clinical dialogue. In assigning diagnoses, clinicians are swayed by family history information, and they should be prepared to observe a mix of different motor disorders to manifest within particular families.
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: All Clinical Neurology, Dystonia, Parkinson's disease/Parkinsonism, Tremor, All Genetics Research Source Type: research