Varenicline for the Treatment of Postural and Gait Dysfunction in Parkinson Disease

Conclusion The results did not suggest that varenicline had an effect on balance in patients with PD. Furthermore, varenicline did not seem to affect cognition. Perhaps, if an objective measure of balance had been used in place of the BBS, the analysis would show a difference between the groups. However, the authors do not recommend further study. Classification of Evidence This study provides Class III evidence that in patients with PD with Hoehn and Yahr stages 2, 3, or 4, varenicline does not improve balance as assessed by the BBS.

http://cp.neurology.org/cgi/content/short/11/6/457?rss=1

Source: Neurology Clinical Practice - December 13, 2021 Category: Neurology Authors: Kapur, S., Vaughan, C., Hawkins, J., Stebbins, G., Hall, D. Tags: All Movement Disorders, Parkinson's disease/Parkinsonism, All Clinical trials, Class III Research Source Type: research