Outbreak of cholera by multidrug resistant Vibrio cholerae O1 in a back ward taluka of Bagalkot, North Karnataka.

Outbreak of cholera by multidrug resistant Vibrio cholerae O1 in a back ward taluka of Bagalkot, North Karnataka. Jpn J Infect Dis. 2015 Mar 13; Authors: Bhattacharya D, Dey S, Roy S, Parande MV, Telsang M, Seema MH, Parande AV, Mantur BG Abstract Cholera is a major cause of illness in the developing world. During the monsoon, sporadic and small clusters of cases of cholera are encountered almost every year in Karnataka, India. During the monsoons in 2013, there was emergence of cholera in Badami, a remote backward area of Bagalkot district in Karnataka, by multi drug resistant V. cholerae O1 serotype Ogawa. The outbreak of diarrhoea started on 5(th) August, 2013, when a 30 year old woman reported with severe dehydration and watery diarrhoea at the Aganwadi Health Centre in Somanakoppa village of Badami. A total of 49 cases suspected of cholera reported during this period in the local health centre/ anganwadi with an attack rate 3.5%. The V. cholerae isolates presented a wide spectrum of resistance involving 4-5 groups of drugs which involves ampicillin, co-trimoxazole, nitrofurantoin, carbenicillin, third generation cephalosporins and showed reduced susceptibility to third generation fluoroquinolones. All the cephalosporin resistant strains were confirmed to produce extended spectrum beta lactamase. All the V. cholerae O1 isolates harboured virulent genes ctxA, ctxB, tcpA El Tor, Tox S, VPI, ToxT, ToxR, ToxRS, ace, zot and tcpP and ...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research