Cervical cancer in pregnancy: diagnosis, staging and treatment

AbstractKey ContentCervical cancer is the commonest gynaecological malignancy diagnosed in pregnancy.Cancer symptoms may mimic complications of pregnancy, thus delaying diagnosis.Staging of cervical cancer in pregnancy is essential to determine an individual management plan.Treatment of cervical cancer in pregnancy is complex and depends on the stage of cancer and the gestation of the pregnancy.Involvement of a multidisciplinary team is essential in the care of a woman with cervical cancer in pregnancy.Learning ObjectivesTo understand how to diagnose, stage and treat cervical cancer in pregnancy.To know the risks to the fetus in each trimester, with regard to the various surgical and chemotherapeutic options available to treat cervical cancer in pregnancy.To understand the psychological effects on a woman of a cancer diagnosis in pregnancy.Ethical IssuesHow should maternal and fetal risks be balanced while investigating and treating cervical cancer in pregnancy?Consideration of termination of pregnancy to allow timely treatment, alternatively risking delay in treatment and progression of disease.
Source: The Obstetrician and Gynaecologist - Category: OBGYN Authors: Tags: REVIEWS Source Type: research

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CONCLUSION: In this long-term follow-up of RRT the recurrence rate is comparable to larger individual studies of minimally invasive or vaginal radical trachelectomy with similar risk profile and follow up. The high pregnancy rate and low rate of premature delivery before 32 weeks GA may promote the use of robot-assisted approach.PMID:34980514 | DOI:10.1016/j.ygyno.2021.12.029
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Source Type: research
We identified the most non-9-valent vaccine covered carcinogenic HPV types, so as to provides a basis for further optimizing screening methods and eliminating cervical cancer in the post-vaccine era. AbstractHuman papillomavirus (HPV) infection is the main cause of female precancerous lesions and cervical cancer. The development and application of HPV prophylactic vaccines have been recognized as a major effective intervention for the control of cervical lesions. However, the infection rate and clinical characters of non-9-valent vaccine covered HPV subtypes are still worth studying. In this retrospective study, we include...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
CONCLUSION: The low HPV prevalence found in university students in Vietnam indicates that they can benefit from HPV vaccination, along with a well-designed HPV health promotion programme.PMID:34972721 | DOI:10.21873/invivo.12697
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
AbstractAlthough the incidence of the various gynecological cancers has been increasing in recent years, long-term survival is now possible for many patients thanks to advances in multimodality treatment. When treating gynecological cancer in adolescent and young adult (AYA) patients who desire future pregnancy, it is necessary to preserve the reproductive organs and their function to prevent loss of fertility. However, because treatment targets these organs, in the large majority of cases, patients must have these organs removed. In the subfield of oncofertility, treatment of the underlying disease takes priority, and the...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
This study aimed to assess the accuracy of predicting pelvic lymph node status using sentinel lymph node (SLN) biopsy with indocyanine green (ICG) and to examine the outcomes of SLN biopsy-guided abdominal radical trachelectomy (ART). Patients with stage IA2-IB2 cervical cancer from January 2009 to January 2021 were included. ICG was injected before ART and SLNs were identified, excised, and assessed intraoperatively using fast-frozen sections. Systemic pelvic lymphadenectomy was subsequently performed. The SLN detection rate, sensitivity, and false-negative rate were determined. Thirty patients desiring fertility preserva...
Source: Current Oncology - Category: Cancer & Oncology Authors: Source Type: research
lae Suciu The human papilloma virus (HPV) infection, caused by a ubiquitous virus typically transmitted through the direct contact of infected organs, either through the skin or mucosa, is the most common sexually transmitted infection, placing young women at a high risk of contracting it. Although the vast majority of cases spontaneously clear within 1–2 years, persistent HPV infection remains a serious concern, as it has repeatedly been linked to the development of multiple malignancies, including cervical, anogenital, and oropharyngeal cancers. Additionally, more recent data suggest a harmful effect of HPV...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
AbstractKey ContentCervical cancer is the commonest gynaecological malignancy diagnosed in pregnancy.Cancer symptoms may mimic complications of pregnancy, thus delaying diagnosis.Staging of cervical cancer in pregnancy is essential to determine an individual management plan.Treatment of cervical cancer in pregnancy is complex and depends on the stage of cancer and the gestation of the pregnancy.Involvement of a multidisciplinary team is essential in the care of a woman with cervical cancer in pregnancy.Learning ObjectivesTo understand how to diagnose, stage and treat cervical cancer in pregnancy.To know the risks to the fe...
Source: The Obstetrician and Gynaecologist - Category: OBGYN Authors: Tags: REVIEWS Source Type: research
This study demonstrated that fertility-sparing treatments may be employed in selected cases of early stage uterine sarcoma.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Systematic Review Source Type: research
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Eur J Obstet Gynecol Reprod Biol. 2021 Sep 17;266:163-168. doi: 10.1016/j.ejogrb.2021.09.017. Online ahead of print.ABSTRACTOBJECTIVES: To evaluate the oncologic and obstetric outcomes of patients with low-risk cervical cancer who underwent conization and lymphatic evaluation to preserve fertility.METHODS: Data were collected retrospectively from September 2013 to February 2021. Eligibility criteria included Women with cervical cancer (aged
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Source Type: research
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