External evaluation of published population pharmacokinetic models of polymyxin B

ConclusionNot all published models were satisfactory in prediction- and simulation-based diagnostics; however, Bayesian forecasting improved the predictability considerably with priors, which can be applied to guide polymyxin B dosing recommendations and adjustments for clinicians.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research