A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19

Med Chem Res. 2021 Dec 2:1-12. doi: 10.1007/s00044-021-02826-2. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic lasting now for well more than a year, nearly 247 million cases have been diagnosed and over 5 million deaths have been recorded worldwide as of November 2021. The devastating effects of the SARS-CoV-2 virus on the immune system lead to the activation of signaling pathways involved in inflammation and the production of inflammatory cytokines. SARS-CoV-2 displays a great deal of homology with other coronaviruses, especially SARS-CoV and MERS-CoV which all display similar components which may serve as targets, namely the Spike (S) protein, the main protease (MPro) which is a chymotrypsin-like protease (CLPro) and RNA-directed RNA polymerase (RdRp). Natural constituents found in traditional herbal medicines, dietary supplements and foods demonstrate activity against SARS-CoV-2 by affecting the production of cytokines, modulating cell signaling pathways related to inflammation and even by direct interaction with targets found in the virus. This has been demonstrated by the application of fluorescence resonance energy transfer (FRET) experiments, assays of cytopathic effect (CPE) and in silico molecular docking studies that estimate binding strength. Glycyrrhizin, flavonoids such as quercetin, kaempferol and baicalein, and other polyphenols are the most common constituents found in Traditional Chinese Medicines that modulate inflammation and cell signaling pat...
Source: Cell Research - Category: Cytology Authors: Source Type: research

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Noncoding RNA Res. 2022 Jan 20. doi: 10.1016/j.ncrna.2022.01.003. Online ahead of print.ABSTRACTTo date the coronavirus family is composed of seven different viruses which were commonly known as cold viruses until the appearance of the severe acute respiratory coronavirus (SARS-CoV) in 2002, the middle east respiratory syndrome coronavirus (MERS) in 2012 and the severe acute respiratory coronavirus 2 (SARS-CoV-2) which caused the COVID-19 global pandemic in 2019. Using bioinformatic approaches we tested the potential interactions of human miRNAs, expressed in pulmonary epithelial cells, with the available coronavirus genom...
Source: Cell Research - Category: Cytology Authors: Source Type: research
ScientificWorldJournal. 2022 Jan 11;2022:5578284. doi: 10.1155/2022/5578284. eCollection 2022.ABSTRACTThe end of the year 2019 was marked by the introduction of a third highly pathogenic coronavirus, after SARS-CoV (2003) and MERS-CoV (2012), in the human population which was officially declared a global pandemic by the World Health Organization (WHO) on March 11, 2020. Indeed, the pandemic of COVID-19 (Coronavirus Disease 19) has evolved at an unprecedented rate: after its emergence in Wuhan, the capital of the province of Hubei of the People's Republic of China, in December 2019, the total number of confirmed cases did n...
Source: The Scientific World Journal - Category: Science Authors: Source Type: research
Soares Archanjo Patricia T. Bozza Thiago Moreno L. Souza Suelen Silva Gomes Dias Vinicius Cardoso Soares Ortrud Monika Barth The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impacted public health and the world economy and fueled a worldwide race to approve therapeutic and prophylactic agents, but so far there are no specific antiviral drugs. Understanding the biology of the virus is the first step in structuring strategies to combat it, and in this context several studies have been conducted with the aim of understanding the replication mechanism of SARS-CoV-2 in v...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Dr Maria Bottazzi says their vaccine, called Corbevax, is unique because they do not intend to patent itA new Covid-19 vaccine is being developed by Texas scientists using a decades-old conventional method that will make the production and distribution cheaper and more accessible for countries most affected by the pandemic and where new variants are likely to originate due to low inoculation rates.The team, led by Drs Peter Hotez and Maria Bottazzi from the Texas Children ’s Hospital Center for Vaccine Development at Baylor College of Medicine, has been developing vaccine prototypes for Sars and Mers since 2011, whic...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Texas Coronavirus Vaccines and immunisation US news World news Science Source Type: news
We report herein our efforts in the design and synthesis of submicromolar covalent inhibitors when the enzymatic activity of the viral protease was used as a screening platform.PMID:34995923 | PMC:PMC8665847 | DOI:10.1016/j.ejmech.2021.114046
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Discussion Despite being hailed by the media as heroes, HCWs face social stigmatization and experienced high levels of anxiety and fear regarding personal safety and the health of their colleagues and family. Health care workers are more likely to seek peer-to-peer psychological support but also benefit from knowing that formal psychological supports are available to them.
Source: Journal of Patient Safety - Category: Health Management Tags: The Health Care Manager Source Type: research
This article summarizes the current pandemic, different strains of SARS-CoV-2, etiology, complexities, surviving medications of COVID-19, and so far, vaccination for the treatment of COVID-19.PMID:34959116 | PMC:PMC8673752 | DOI:10.1016/j.biopha.2021.112550
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSION: COVID-19 is a new disease that has become a pandemic. This disease should be watched out for because transmission is relatively fast, has a mortality rate that cannot be ignored, and there is no definitive therapy. There are still many knowledge gaps in this field, so further studies are needed.PMID:34929907 | DOI:10.1016/j.gaceta.2021.10.089
Source: Gaceta Sanitaria - Category: International Medicine & Public Health Authors: Source Type: research
Eur Respir Rev. 2021 Dec 15;30(162):210194. doi: 10.1183/16000617.0194-2021. Print 2021 Dec 31.ABSTRACTAcute manifestations of SARS-CoV-2 infection continue to impact the lives of many across the world. Post-acute sequelae of coronavirus disease 2019 (COVID-19) may affect 10-30% of survivors of COVID-19, and post-acute sequelae of COVID-19 (PASC)-pulmonary fibrosis is a long-term outcome associated with major morbidity. Data from prior coronavirus outbreaks (severe acute respiratory syndrome and Middle East respiratory syndrome) suggest that pulmonary fibrosis will contribute to long-term respiratory morbidity, suggesting ...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Source Type: research
FINDINGSResearchers at the  Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified rare, naturally occurring T cells that are capable of targeting a protein found in SARS-CoV-2 and a range of other coronaviruses.The findings suggest that a component of this protein, called viral polymerase, could potentially be added to COVID-19 vaccines to create a longer-lasting immune response and increase protection against new variants of the virus.BACKGROUNDMost COVID-19 vaccines use part of the spike protein found on the surface of the virus to prompt the immune system to produc...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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