Evaluating microglial phenotypes using single-cell technologies

Trends Neurosci. 2021 Dec 3:S0166-2236(21)00228-9. doi: 10.1016/j.tins.2021.11.001. Online ahead of print.ABSTRACTRecent single-cell technologies have enabled researchers to simultaneously assess the transcriptomes and other modalities of thousands of cells within their spatial context. Here, we have summarized available single-cell methods for dissociated tissues and tissue slides with respect to the specifics of microglial biology. We have focused on next-generation-based technologies. We review the potential of these single-cell sequencing methods and newer multiomics approaches to extend the understanding of microglia function beyond the status quo.PMID:34872773 | DOI:10.1016/j.tins.2021.11.001
Source: Trends in Neurosciences - Category: Neuroscience Authors: Source Type: research