Identification of a novel replication-competent hepatitis C virus variant that confers the sofosbuvir resistance

In conclusion, we identified the combination of two NS5B mutations S282T and K74R as a novel RAS that confers a substantial resistance to SOF while retains the HCV replication capacity.PMID:34864126 | DOI:10.1016/j.antiviral.2021.105224

Source: Antiviral Research - December 5, 2021 Category: Virology Authors: Steve Leumi Mingzhe Guo Jie Lu Zhaoning Wang Tianyu Gan Lin Han Jackline Ngari Yimin Tong Xiaogang Xiang Qing Xie Lanfeng Wang Jin Zhong Source Type: research