A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia

Conditions:   Breast Cancer;   Mastectomy;   Pain, Chronic;   Pain, Post Operative Interventions:   Procedure: Opioid-free anesthesia;   Procedure: Conventional opioid-based anesthesia Sponsor:   Gangnam Severance Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conditions:   Breast Cancer;   Mastectomy;   Pain, Chronic;   Pain, Post Operative Interventions:   Procedure: Opioid-free anesthesia;   Procedure: Conventional opioid-based anesthesia Sponsor:   Gangnam Severance Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: Intraoperative low dose ketamine infusion did not improve the overall quality of recovery on POD 1 in patients undergoing breast cancer surgery.PMID:34807494 | DOI:10.1111/ijcp.15010
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Source Type: research
BackgroundThe effectiveness of paravertebral block in preventing chronic pain after breast surgery remains controversial. The primary hypothesis of this study was that paravertebral block reduces the incidence of chronic pain 3 months after breast cancer surgery.MethodsIn this prospective, multicenter, randomized, double-blind, parallel-group, placebo-controlled study, 380 women undergoing partial or complete mastectomy with or without lymph node dissection were randomized to receive preoperative paravertebral block with either 0.35 ml/kg 0.75% ropivacaine (paravertebral group) or saline (control group). Systemic multimoda...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
AANA J. 2021 Aug;89(4):291-298.ABSTRACTPatients with breast cancer often require several procedures requiring anesthesia, such as central venous catheter placements, mastectomies, lymph node dissections, and reconstructive surgeries. Recent research findings have suggested there may be a reduced risk of cancer recurrence and chronic pain with specific anesthetic techniques. Regional techniques, total intravenous anesthetics, and select adjuncts have been reviewed to identify their role in breast cancer recurrence and chronic pain. A review of the pathophysiology as it pertains to volatile anesthetics, propofol as a total i...
Source: AANA Journal - Category: Anesthesiology Authors: Source Type: research
J Clin Anesth. 2021 Jun 24;74:110410. doi: 10.1016/j.jclinane.2021.110410. Online ahead of print.ABSTRACTSTUDY OBJECTIVE: To determine whether ultrasound-guided serratus anterior plane block (SAPB) is associated with decreased prevalence of chronic postsurgical pain (CPSP) after modified radical mastectomy.DESIGN: Randomized, double-blind, placebo-controlled study.SETTING: University hospital.PATIENTS: We enrolled 198 patients aged 18-65 years with American Society of Anesthesiologists physical status I to II, undergoing unilateral modified radical mastectomy.INTERVENTIONS: Patients were randomly allocated to receive SAPB ...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
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