K-core decomposition of a protein domain co-occurrence network reveals lower cancer mutation rates for interior cores.
CONCLUSION: Mutations and domain co-occurrence networks provide a framework for understanding hierarchal designs in protein function from a network perspective. This study provides evidence that a majority of protein domains in the inner core of the DCN have a lower mutation frequency and that protein domains present in the peripheral regions of the k-core contribute more heavily to the disease. These findings may contribute further to drug development.
PMID: 25767694 [PubMed - as supplied by publisher]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Emerson AI, Andrews S, Ahmed I, Azis TK, Malek JA Tags: J Clin Bioinforma Source Type: research
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