The Study of Cerebral Blood Flow Variations during Brain Metastasis Radiotherapy

Purpose: To investigate the cerebral blood flow (CBF) variations during brain metastases (BMs) radiotherapy (RT) applying with MR 3D-arterial spin labeling (ASL). Materials and Methods: A total of 26 BMs patients with 54 tumors were retrospectively enrolled. MR examinations were performed before and during RT (30-50 Gy) with a total dose of 36-60 Gy (12-30 fractions) including contrast-enhanced T1-weighted, T2 Flair and 3D-ASL images. The relationship between CBF changes and the largest  cross-sectional area changes in BMs was investigated. And CBF changes in BMs, normal brain tissue, and peritumoral edema areas were analyzed under different dose gradients that was divided into 10 Gy intervals. Results: The largest cross-sectional areas and CBF of 54 BMs decreased by 26.46% and 29.64% respectively during RT (P0.05). The rates of CBF decrease in BMs were 33.75%, 24.61% and 27.55% at 30-40, 40-50 and>50 Gy, respectively (P 50 Gy, the CBF decreased by 7.65%, 11.12%, 18.42%, 20.23%, 19.79% and 17.89%, respectively (P
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research