Massively parallel sequencing in hereditary prostate cancer families reveals a rare risk variant in the DNA repair gene, RAD51C
Global statistics show that prostate cancer (PrCa) is the second most common non-cutaneous cancer diagnosed in men, and currently, it is the most commonly diagnosed cancer in Australian men [1]. While PrCa is a clinically complex, heterogeneous disease, it is one of the most heritable common cancers, with family history a strong predictor of susceptibility [2]. However, the identification of rare, high-risk germline variants for PrCa has lagged significantly behind other heritable cancers [3]. Massively parallel sequencing (MPS) applied to large families with a dense aggregation of disease, where genetic complexity is reduced and rare variants are enriched, has proven successful for rare variant discovery [4].
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: James R. Marthick, Kelsie Raspin, Georgea R. Foley, Nicholas B. Blackburn, Annette Banks, Shaun Donovan, Roslyn C. Malley, Matthew A. Field, Janet L. Stanford, Elaine A. Ostrander, Liesel M. FitzGerald, Joanne L. Dickinson Tags: Letter to the Editor Source Type: research
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