Hypoxia-Induced Aquaporin-3 Changes Hepatocellular Carcinoma Cell Sensitivity to Sorafenib by Activating the PI3K/Akt Signaling Pathway Retraction

Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

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Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-022-03102-z. Online ahead of print.ABSTRACTNanoparticles can potentially cause adverse effects on cellular and molecular level. The present study aimed to investigate the histopathological changes and DNA damage effects of magnetite nanoparticles (MNPs) on female albino mice model with Ehrlich solid carcinoma (ESC). Magnetite nanoparticles coated with L-ascorbic acid (size ~ 25.0 nm) were synthesized and characterized. Mice were treated with MNPs day by day, intraperitoneally (IP), intramuscularly (IM), or intratumorally (IT). Autopsy samples were taken from the solid t...
Source: Cell Research - Category: Cytology Authors: Source Type: research
In this study, a programmed death ligand 1 (PD-L1)-conjugated nanoliposome was constructed for co-delivery of paclitaxel (PTX) and P-glycoprotein (P-gp) inhibitor zosuquidar (ZSQ) to overcome MDR in human HCC cells and tumors in vivo. Transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA) were used to examine the nanoparticles morphology and size; PD-1-conjugated PTX and ZSQ-loaded nanoliposomes (PD-PZLP) revealed a spherical shape with a size of 139.5 ± 10.7 nm. Then, the physicochemical properties, as well as the drug loading capacity, release profile, cellular uptake, and cytotoxicity of ...
Source: Cell Research - Category: Cytology Authors: Source Type: research
ConclusionThis review provides a platform for HCC and liver xenografts and highlights studies performed to understand gene functionality and drug efficacy in vivo in zebrafish.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
Br J Clin Pharmacol. 2022 Jan 13. doi: 10.1111/bcp.15233. Online ahead of print.ABSTRACTAIMS: Patients with advanced urothelial carcinoma (UC) who progress after platinum-based chemotherapy have a poor prognosis, and there is a medical need to improve current treatment options. Ramucirumab plus docetaxel significantly improved progression-free survival but not overall survival (OS) in platinum-refractory advanced UC (RANGE trial; NCT02426125). Here, we report the exposure-response (ER) of ramucirumab plus docetaxel using data from the RANGE trial.METHODS: Pharmacokinetic (PK) samples were collected (cycle 1-3, 5 ,9 [day 1]...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: The expression of ARID1A could be used to predict the outcome of HCC. It is closely related to tumor immune cell infiltration.PMID:35028302 | PMC:PMC8752298 | DOI:10.1155/2022/3163955
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
CONCLUSION: The study explored the dysregulation mechanism and potential biomarkers of immune-related genes and further identified the influence of immune cells on the prognosis of HCC, providing a theoretical basis for the prognosis prediction and immunotherapy in HCC patients.PMID:35027925 | PMC:PMC8752260 | DOI:10.1155/2022/5313149
Source: Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research
Br J Clin Pharmacol. 2022 Jan 13. doi: 10.1111/bcp.15233. Online ahead of print.ABSTRACTAIMS: Patients with advanced urothelial carcinoma (UC) who progress after platinum-based chemotherapy have a poor prognosis, and there is a medical need to improve current treatment options. Ramucirumab plus docetaxel significantly improved progression-free survival but not overall survival (OS) in platinum-refractory advanced UC (RANGE trial; NCT02426125). Here, we report the exposure-response (ER) of ramucirumab plus docetaxel using data from the RANGE trial.METHODS: Pharmacokinetic (PK) samples were collected (cycle 1-3, 5 ,9 [day 1]...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
Medicine (Baltimore). 2022 Jan 14;101(2):e28249. doi: 10.1097/MD.0000000000028249.ABSTRACTRATIONALE: Lung cancer is the most common cause of cancer-related deaths worldwide. Approximately 50% of patients is metastatic at diagnosis and the most common metastatic sites are bone, lungs, brain, adrenal glands, liver, and extra thoracic lymph nodes. The occurrence of gastrointestinal metastasis from lung carcinoma is rare and seems more commonly related to small cell lung cancer compared to non-small cell lung cancer (NSCLC).PATIENT INFORMATION AND DIAGNOSIS: A 78-year-old man with completely surgically resected NSCLC and no in...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: The study explored the dysregulation mechanism and potential biomarkers of immune-related genes and further identified the influence of immune cells on the prognosis of HCC, providing a theoretical basis for the prognosis prediction and immunotherapy in HCC patients.PMID:35027925 | PMC:PMC8752260 | DOI:10.1155/2022/5313149
Source: Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research
Conclusion Overall, our data confirm the efficacy of lenvatinib as first-line treatment and did not revea l new or unexpected side effects in a large retrospective Caucasian real-world cohort, supporting the use of lenvatinib as meaningful alternative for patients that cannot be treated with IO-based combinations in first-line HCC.
Source: Liver Cancer - Category: Cancer & Oncology Source Type: research
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