An open-label, single-arm, multi-center, phase II clinical trial of single-dose 131Imeta-iodobenzylguanidine therapy for patients with refractory pheochromocytoma and paraganglioma

ConclusionA single dose131I-mIBG therapy was well tolerated by patients with PPGL, and statistically significantly reduced catecholamine levels compared to the threshold response rate, which may lead to an improved prognosis for these patients.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research

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Conclusions (i.e., comparable) are based on an overlap of pairwise 95 percent credible intervals.1c. PASI 90 is defined as at least 90 percent improvement from baseline in the PASI score. The PASI score grades the amount of surface area on each body region that is covered by PsO plaques and the severity of plaques for their redness, thickness, and scaliness.13 PASI 90 was not a controlled endpoint in DISCOVER-1 or -2.8,9d. TREMFYA q4w dosing is not currently FDA-approved.2e. The PsA-modified vdH-S score combines erosion and joint space narrowing scores derived from radiographs of joints in body regions impacted by PsA.14 T...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
J Am Dent Assoc. 2022 Jan 22:S0002-8177(21)00620-6. doi: 10.1016/j.adaj.2021.09.012. Online ahead of print.ABSTRACTBACKGROUND: The authors' aim was to describe 2 endodontically treated mandibular first premolars with apical and mesiolingual radiolucencies on radiographs with different approaches that were resolved with intentional replantation.CASE DESCRIPTION: In case 1, a 58-year-old man reported biting sensitivity on endodontically treated mandibular first premolar with good quality restorations. A periapical radiograph (PAX) and cone-beam computed tomography (CBCT) image revealed 2 low-density areas located at the apic...
Source: Journal of the American Dental Association - Category: Dentistry Authors: Source Type: research
CONCLUSIONS: The proposed HIPEC technique has demonstrated its clinical safety in the treatment of PC, no long-term negative impact on the QOL of patients, and better oncological results for ovarian cancer.PMID:35079235 | PMC:PMC8768048 | DOI:10.5114/wo.2021.112038
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSIONS: Systemic corticosteroids showed no preliminary benefits in adults with parapneumonic effusions. Clinical trial registration available at https://anzctr.org.au/, ID: ACTRN12618000947202.PMID:35081010 | DOI:10.1164/rccm.202107-1600OC
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Source Type: research
CONCLUSION: The three-part Lawrence and Botte classification system demonstrated a concerningly low level of interrater reliability with an observed agreement of 77% compared with a chance agreement of 33%. The primary source of concern is the assessment of the interface between Zone 2 and Zone 3, which proved much less reliable than that between Zone 1 and Zone 2. This suggests that previous studies of isolated Zone 1 fractures likely contain a homogeneous fracture cohort, whereas studies of Zone 2 or Zone 3 fractures are likely to include a mixture of fracture types. In practice, the consensus treatment of fifth metatars...
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Source Type: research
In this study, we describe percutaneous access to the lumbar disc and insertion of an expandable titanium cage through Kambin's triangle without facetectomy. The objective of this study is to determine the feasibility as well as clinical and radiographical outcomes of completely percutaneous lumbar interbody fusion (percLIF) using an expandable titanium cage through Kambin's triangle.METHODS: A retrospective review of patients undergoing single-level percLIF for grade 1 lumbar spondylolisthesis via Kambin's triangle using an expandable titanium cage was performed. Demographic information, Oswestry Disability Index (ODI), p...
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
We present two cases of AOT, the first case concerns a 23-year-old patient with an AOT located in the maxilla and the second case involves a 37-year-old patient presenting an AOT with mandibular localization.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
ConclusionA single dose131I-mIBG therapy was well tolerated by patients with PPGL, and statistically significantly reduced catecholamine levels compared to the threshold response rate, which may lead to an improved prognosis for these patients.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
AbstractObjectiveGiven the rarity of refractory pheochromocytoma and paraganglioma (PPGL), outcomes and prognostic factors after131I-metaiodobenzylguanidine (131I-mIBG) treatment still remain unclear. Therefore, this study evaluated whether baseline characteristics at initial131I-mIBG therapy and imaging response to repeated131I-mIBG therapy could be prognostic factors for refractory PPGL.MethodsAll patients [n = 59 (male/female = 35/24), median age; 49.3 years] with refractory PPGL who received131I-mIBG therapy at our institution between September 2009 and September 2019 were retrospective...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Conclusions: TMZ is effective and safe in MPP patients, and, it may work better on patients with SDHB-related MPP. Measurement of MGMT expression might help assess the tumor sensitivity to TMZ but this needs further systematic investigation.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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