Cataract Surgery Linked to Lower Dementia Risk in Older Adults

Older adults who undergo cataract surgery are at lower risk of developing dementia compared with those who do not undergo surgery, reports astudy published today inJAMA Internal Medicine. A similar effect was not observed in older adults who received surgery for glaucoma.“These results have implications for the care of older persons who are uniquely at higher risk for both impaired vision due to cataract and impaired cognition due to neurodegeneration observed in age-related dementia,” wrote Cecilia S. Lee, M.D., M.S., of the University of Washington and colleag ues. “Given the substantial degree by which cataract extraction is associated with lower risk of dementia and its persistent effect beyond 10 years, the improvement in quality of life for the affected individuals and their [families] is likely considerable.”Lee and colleagues assessed data from the Adult Changes in Thought study, an ongoing longitudinal study that monitors the cognitive health of adults 65 and older who are members of Kaiser Permanente Washington. From this sample, they identified 3,038 adults who received a cataract diagnosis before the onset of any dementia; 1,382 underwent cataract surgery and 1,656 did not. The researchers tracked the outcomes of the study participants from the moment of cataract diagnosis until death, study dropout, or their most recent clinical visit.In total, 853 adults developed dementia during the follow-up. After adjusting for numerous variables (incl...
Source: Psychiatr News - Category: Psychiatry Tags: Adult Changes in Thought cataract dementia glaucoma JAMA Internal Medicine older adults risk Source Type: research

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In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development. CYTOR Upregulation as a Path to Improved Muscle Function in Later Life https://www.fightaging.org/archives/2021/12/cytor-u...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Today's research materials report on a solid correlation between cataract surgery to restore vision and lower risk of later dementia. This provides support for the view that a reduced flow of sensory information to the brain accelerates the onset of neurodegeneration and loss of function with age. This is quite distinct from the usual set of underlying biochemical processes that are investigation in connection with cognitive decline and dementia: the accumulation of molecular waste in the brain; the chronic inflammation of brain tissue; the loss of mitochondrial function; the dysfunction of the vascular system leading to l...
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CONCLUSIONS: AMD, cataract and DRED but not glaucoma are associated with an increased risk of dementia. Individuals with both ophthalmic and systemic conditions are at higher risk of dementia compared with those with an ophthalmic or systemic condition only.PMID:34518160 | DOI:10.1136/bjophthalmol-2021-319508
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
ConclusionsThese findings demonstrate that the Look Out! test is applicable in mental health settings, helping to identify those with visual impairments and raising the need to complete the screening tool in all patients admitted to inpatient mental health facilities.
Source: Age and Ageing - Category: Geriatrics Source Type: research
DISCUSSION: Differential associations between specific ophthalmic conditions and dementia subtypes may elucidate pathophysiologic pathways. Lack of association between glaucoma and dementia was most surprising from these analyses.PMID:33788406 | DOI:10.1002/alz.12313
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Source Type: research
Abstract Mild cognitive impairment (MCI), as a preclinical phase of dementia, provides an invaluable time window for intervention. Besides several proposed modifiable risk factors, the associations of MCI with dietary habits and bowel movement are not well clarified. We thus conducted a cross-sectional study of community-living Singapore elderly and focused on the relationship of clinically diagnosed MCI with dietary habits and bowel movement frequencies. The multiple logistic regression results showed that frequent (≥4 days per week) fruit consumption (P = 0.004), active (≥4 days per week) bowel movement wi...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
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Many aspects of aging correlate with one another, even those with quite different underlying mechanisms and proximate causes. The various forms of root cause damage that result in the aging process, as well as their downstream consequences, all interact with one another. So whether or not any specific correlation teaches us anything about the way in which aging works under the hood is very dependent on the details. That loss of vision and hearing correlate with dementia risk is known, but the relative contribution of different mechanisms is up for debate. How much is due to similar biochemical mechanisms of damage in nervo...
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Conclusions: Some comorbidities were present in both the AD and control groups, while others were found in the AD group and not in the control group, and vice versa.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum. Blood Metabolites as a Marker of Frailty https://www.fightaging.org/archives/2020/04/blood-metabolites-as-a-marker-of-frailty/ Frailty in older people is usually diagnosed in a sympt...
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