Modifiable Risk Factors of Dementia in Older Adults With Epilepsy: An Opportunity to Flatten the Curve?

Epilepsy Curr. 2021 Mar 23;21(3):162-164. doi: 10.1177/15357597211002870. eCollection 2021 May-Jun.NO ABSTRACTPMID:34867093 | PMC:PMC8609587 | DOI:10.1177/15357597211002870
Source: Epilepsy Curr - Category: Neurology Authors: Source Type: research

Related Links:

AbstractNuclear medicine neuroimaging is able to show functional and molecular biologic abnormalities in various neuropsychiatric diseases. Therefore, it has played important roles in the clinical diagnosis and in research on the normal and pathological states of the brain. More than 400 outstanding studies have been conducted by Korean researchers over the past 60  years. In the 1990s, when multiheaded single-photon emission computed tomography (SPECT) scanners were first introduced in South Korea, stroke research using brain perfusion SPECT was conducted. With the spread of positron emission tomography (PET) scanner...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Neurological disorders related to neuroinfections are highly prevalent in Sub-Saharan Africa (SSA), constituting a major cause of disability and economic burden for patients and society. These include epilepsy, dementia, motor neuron diseases, headache disorders, sleep disorders, and peripheral neuropathy. The highest prevalence of human immunodeficiency virus (HIV) is in SSA. Consequently, there is a high prevalence of neurological disorders associated with HIV infection such as HIV-associated neurocognitive disorders, motor disorders, chronic headaches, and peripheral neuropathy in the region. The pathogenesis of these n...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Curr Drug Res Rev. 2021 Dec 31. doi: 10.2174/2589977514666211231141401. Online ahead of print.ABSTRACTBACKGROUND: A link between inflammatory diseases, e.g., epilepsy, dementia, diabetes, and COVID-19, has been established. For instance, observational studies with several individuals established that people with epilepsy have shown an enhanced incidence of manifesting dysfunctions related to cognition, e.g., dementia, while people with dementia have a higher incidence of manifesting epilepsy, thus an evident bidirectional relationship between epilepsy and dementia might occur. In addition, epilepsy commonly cooccurs in pat...
Source: Epilepsy Curr - Category: Neurology Authors: Source Type: research
Neurobiol Dis. 2021 Dec 28;163:105604. doi: 10.1016/j.nbd.2021.105604. Online ahead of print.ABSTRACTDentatorubral-pallidoluysian atrophy (DRPLA) is a devastating genetic disease presenting myoclonus, epilepsy, ataxia, and dementia. DRPLA is caused by the expansion of a CAG repeat in the ATN1 gene. Aggregation of the polyglutamine-expanded ATN1 protein causes neuro-degeneration of the dentatorubral and pallidoluysian systems. The expanded CAG repeats are unstable, and ongoing repeat expansions contribute to disease onset, progression, and severity. Inducing contractions of expanded repeats can be a means to treat DRPLA, fo...
Source: Neurobiology of Disease - Category: Neurology Authors: Source Type: research
Conditions:   Dementia;   Alzheimer Disease;   Epilepsy;   Sleep Disorder;   Circadian Rhythm Disorders;   Healthy Interventions:   Diagnostic Test: EEG,PSG;   Diagnostic Test: biosample collection (blood and CSF);   Diagnostic Test: neuropsychological testing;   Diagnostic Test: actigraphy;   Diagnostic Test: clinician assessment Sponsors:   Neurological Institute of Athens;   Rabin Medical Center;   Fundació Institut de Recerca de l'Hospital de la Sant...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractLafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates —the so-called Lafora Bodies (LBs)—in several organs. The accumulation of LBs in the brain underlies the neurological phenotype of the disease. LBs are composed of abnormal glycogen and various associated proteins, including p62, an autophagy adaptor that participates in the aggregation and clea rance of misfolded proteins. To study the role of p62 in the formation of LBs and its participation in the pathology of LD, we generated a mouse model of the disease (malinKO) lacking p62. D...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
CNS Neurol Disord Drug Targets. 2021 Dec 21. doi: 10.2174/1871527321666211221162104. Online ahead of print.ABSTRACTEpilepsy is known as one of the major challenges for medical science. The sudden appearance of a seizure has been a significant health emergency as it may lead to further complications. Although key advancement have been achieved in terms of pharmacological approaches for epilepsy, many issues remain uncertain. Lipid carriers have been at the forefront, especially in neurodegenerative diseases such as epilepsy, Alzheimer's, dementia, etc. The blood-brain barrier still appears to be a major impediment in the su...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Source Type: research
More News: Dementia | Epilepsy | Neurology