Continuous Glucose Monitoring and HbA1c in Cystic Fibrosis: Clinical Correlations and Implications for CFRD Diagnosis

CONCLUSIONS: CGM measures of hyperglycemia and glycemic variability are superior to HbA1c in distinguishing those with and without CFRD. CGM-derived AG is strongly correlated with HbA1c in adults with CF, with a similar relationship to other diabetes populations. Future studies are needed to investigate CGM as a diagnostic and screening tool for CFRD.PMID:34850006 | DOI:10.1210/clinem/dgab857
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Source Type: research

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Pancreatic injury in cystic fibrosis (CF) begins in utero, as evidenced by an increase in immunoreactive trypsinogen values in new-born screening. Cystic-fibrosis-related diabetes (CFRD), a comorbidity of CF, differs from Type 1 or Type 2 diabetes mellitus. It occurs primarily due to impaired insulin secretion and worsens prognosis, because it is associated with decreased lung function and poor nutritional status [1]. Dysglycaemia frequency increases over time amongst children, adolescents and young adults.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Cystic fibrosis-related diabetes (CFRD) is an important and well-established complication of cystic fibrosis (CF), affecting up to 50% of patients by the third decade of life [1]. This unique form of diabetes occurs most commonly in those with severe CF mutations, increases with age, and results from anatomical and functional pancreatic abnormalities as well as defective CFTR function within the pancreatic β cells [2–4]. CFRD is neither Type 1 (T1DM) nor Type 2 diabetes mellitus (T2DM), but shares clinical characteristics of both [4].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
Vasoactive intestinal peptide (VIP), which was discovered in the 1970s by Said and Mutt, is a 28-residue polypeptide that was first isolated from porcine small intestine as a vasodilatory peptide [1,2]. It belongs to a superfamily of brain-gut peptide hormones structurally related to secretin, glucagon and pituitary adenylyl cyclase-activating peptide (PACAP) [2,3]. VIP mediates its functions through the G protein-coupled receptors VPAC1 (VIP receptor type 1) or VPAC2 (VIP receptor type 2) [4]. VIP is expressed in the central and peripheral nervous systems as well as in the digestive, respiratory, reproductive and cardiova...
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Although type 1 diabetes mellitus and, to a lesser extent, type 2 diabetes mellitus, are the prevailing forms of diabetes in youth, atypical forms of diabetes are not uncommon and may require etiology-specific therapies. By some estimates, up to 6.5% of children with diabetes have monogenic forms. Mitochondrial diabetes and cystic fibrosis related diabetes are less common but often noted in the underlying disease. Atypical diabetes should be considered in patients with a known disorder associated with diabetes, aged less than 25  years with nonautoimmune diabetes and without typical characteristics of type 2 diabetes ...
Source: Endocrinology and Metabolism Clinics of North America - Category: Endocrinology Authors: Source Type: research
Hypoglycemia is a common and feared complication of insulin therapy. As in type 1 and type 2 diabetes, people with cystic fibrosis related diabetes are also at risk for hypoglycemia related to insulin therapy. Spontaneous hypoglycemia is also common in patients with CF without diabetes, who are not on glucose lowering medications. Spontaneous hypoglycemia in CF may also occur during or after an oral glucose tolerance test. In this review, we will discuss the definition, epidemiology, pathophysiology and impact of hypoglycemia, with a focus on people with cystic fibrosis.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
Publication date: November 2018Source: Pharmacological Research, Volume 137Author(s): D. Visca, P. Pignatti, A. Spanevello, E. Lucini, E. La RoccaAbstractDiabetes is a common metabolic disorder affecting the entire body with high morbidity and mortality worldwide. The major complications related to diabetes are mostly due to the macrovascular and microvascular bed impairment due to metabolic, hemodynamic and inflammatory factors. However, studies over the past decades have added also the lung as a target organ in both type 1 and type 2 diabetes. Diabetes has always been addressed as a major comorbidity conditioning the dis...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 9 October 2018Source: Pharmacological ResearchAuthor(s): D. Visca, P. Pignatti, A. Spanevello, E. Lucini, E. La RoccaAbstractDiabetes is a common metabolic disorder affecting the entire body with high morbidity and mortality worldwide. The major complications related to diabetes are mostly due to the macrovascular and microvascular bed impairment due to metabolic, hemodynamic and inflammatory factors. However, studies over the past decades have added also the lung as a target organ in both type 1 and type 2 diabetes. Diabetes has always been addressed as a major comorbidity conditioning t...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Abstract Exocrine pancreatic insufficiency (EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases (diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin (CCK); celiac or inflammatory bowel disease (IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery (asynchrony between motor and secret...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Type 1 (T1) and type 2 (T2) diabetes mellitus (DM) are the most commonly recognized disease states characterized by hyperglycemia. However, diabetes compromises many disorders with hyperglycemia as a common feature. Other forms of diabetes include gestational diabetes, neonatal diabetes, cystic fibrosis-related diabetes, latent autoimmune diabetes in adults, and maturity-onset diabetes of the young (MODY). MODY affects pediatric patients and accounts for 2 –5% of all diabetes cases (Timsit, Bellanné-Chantelot, Dubois-Laforgue,&Velho, 2005).
Source: Journal of Pediatric Nursing - Category: Nursing Authors: Tags: PENS Department Source Type: research
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