Effect of Probiotics in Alzheimer's Disease

Condition:   Alzheimer Disease Interventions:   Dietary Supplement: Low dose probiotics;   Dietary Supplement: Normal dose probiotics Sponsor:   Hsieh-Hsun Ho Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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The researchers studied samples of brain tissue from people with and without Alzheimer's disease.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia subscribers-only Source Type: blogs
This article discussed the pathophysiology of dementia, as well as a list of herbal medications that can easily cross the BBB and have a therapeutic effect on dementia.PMID:35031512 | DOI:10.1016/j.arr.2022.101560
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Source Type: research
CONCLUSION: The preliminary results demonstrated that the developed RPM approach has the potential to monitor progression in high-risk populations with AD.PMID:35032179 | DOI:10.1007/s00259-022-05687-y
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-021-02938-1. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a complex and progressive neurodegenerative disease with impaired synapse, imbalanced mineral metabolism, protein mis-folding and aggregation. Bis(ethylmaltolato)oxidovanadium(IV) (BEOV), an organic bioactive vanadium compound with low toxicity and high bioavailability, has been studied as therapeutic agent against tuberculosis and diabetes. However, its neuroprotective effects have rarely been reported. Therefore, in this study, the potential application of BEOV in intervening AD cognitive dysfuncti...
Source: Biological Trace Element Research - Category: Biology Authors: Source Type: research
J Cell Commun Signal. 2022 Jan 15. doi: 10.1007/s12079-021-00663-x. Online ahead of print.ABSTRACTThe accumulation and propagation of misfolded proteins in the brain is a pathological hallmark shared by many neurodegenerative diseases, such as the depositions of β-amyloid and hyperphosphorylated tau proteins in Alzheimer's disease. Initial evidence shows the role of nitric oxide synthases in the development of neurodegenerative diseases. A recent, in an exciting paper (Bourgognon et al. in Proc Natl Acad Sci USA 118, 1-11, 2021. 10.1073/pnas.2009579118) it was shown that the inducible nitric oxide synthase plays an im...
Source: Journal of Cell Communication and Signaling - Category: Molecular Biology Authors: Source Type: research
AbstractAlzheimer ’s disease (AD) is an irreversible, progressive brain disorder that impairs memory and cognitive function. Dysregulation of the amyloid-β (Aβ) pathway and amyloid plaque accumulation in the brain is a hallmark of AD. Aducanumab is a human, immunoglobulin gamma 1 (IgG1) monoclonal antibody (mAb) targeting aggregated forms of Aβ. In phase 1b and phase 3 studies, aducanumab reduced Aβ plaques in a dose dependent manner, as measured by standard uptake value ratio (SUVR) of amyloid PET imaging. The goal of this work was to develop a quantitative systems pharmacology (QSP) model descri...
Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Tags: ARTICLE Source Type: research
For the first time, scientists have identified a rare population of potentially toxic senescent cells in human brains that can serve as a target for a new Alzheimer ’s disease treatment. The study, published in the Dec.10 edition of the journal Nature Aging, was led by Miranda Orr, an assistant professor of gerontology and geriatric medicine, at Wake Forest School of Medicine and research health scientist at the W.G. Hefner VA Medical Center, and Habil Zare, an assistant professor of cell systems…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
In this study, administration of fingolimod was initiated after behavioral symptoms are known to emerge, at 6  months of age. Treatment continued to 12 months when behavioral tests were performed and thereafter histological and biochemical analysis was conducted on postmortem tissue. The results demonstrate that fingolimod reverses deficits in spatial working memory at 8 and 12 months of age as measured by novel object location and Morris water maze tests. Inflammation in the brain is alleviated as demonstrated by reduced Iba1-positive and CD3-positive cell number, less ramified microglial morphology, and im...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
ConclusionThe preliminary results demonstrated that the developed RPM approach has the potential to monitor progression in high-risk populations with AD.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
AbstractPurposeTo compare two artificial intelligence software packages performing normative brain volumetry and explore whether they could differently impact dementia diagnostics in a clinical context.MethodsSixty patients (20 Alzheimer ’s disease, 20 frontotemporal dementia, 20 mild cognitive impairment) and 20 controls were included retrospectively. One MRI per subject was processed by software packages from two proprietary manufacturers, producing two quantitative reports per subject. Two neuroradiologists assigned forced-choi ce diagnoses using only the normative volumetry data in these reports. They classified ...
Source: Neuroradiology - Category: Radiology Source Type: research
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